Compound class:
Synthetic organic
Comment: Compound 3bb is the most potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity identified from a SAR series by Dziedzic et al. (2015) [1]. It is referred to as quinoline 20 in [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Inhibitor 3bb is >2000-fold more potent than ISO-1, and almost 300-fold more potent than Orita-13 when evaluated in the same assay [1]. |
Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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