PEN   Click here for help

GtoPdb Ligand ID: 9140

Comment: Rat PEN is one of the active fragments cleaved from pro-protein proSAAS. It is amino acids 221-242 of proSAAS. PEN appears to be involved in the regulation of feeding, possibly in concert with the BigLEN-GPR171 ligand-receptor system [1].
Species: Rat
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR83 Mm Agonist Agonist 8.1 pKd - 1
pKd 8.1 (Kd 8x10-9 M) [1]
Description: N-terminally tyrosinated radioidodinated rPEN binding to mouse GPR83 in hypothalamic membrane preparations.