Synonyms: [3-(aminocarbonyl)furoxan-4-yl]methyl salicylate [1]
Compound class:
Synthetic organic
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Bioactivity Comments |
AT38 blocks in vivo production of reactive nitrogen species (RNS; e.g. peroxynitrite) within the tumour, which increases access of T lymphocytes to the tumour mass [1]. In vivo treatment of tumour bearing mice with AT38 appears to decrease expression of iNOS and arginase enzymes (ARG1 and ARG2) and this is accompanied by increased T cell infiltration into the tumour core [1]. |