Kir2.4
|
|
|
Hs |
Gating inhibitor (Extracellular H+) |
Antagonist |
7.1 |
pKi |
- |
3 |
|
⤷ |
pKi
7.1
[3]
Voltage:
-120.0 mV
|
Kir2.3
|
|
|
Hs |
Gating inhibitor (Extracellular H+) |
Antagonist |
6.7 – 7.4 |
pKi |
- |
1,6,11 |
|
⤷ |
pKi
6.7 – 7.4
[1,11]
Voltage:
-120.0 – -100.0 mV
pKi
6.8 – 6.8
[6,11]
Voltage:
-150.0 – 100.0 mV
|
Kir4.2
|
|
|
Rn |
Gating inhibitor (Intracellular H+) |
Antagonist |
6.7 – 7.1 |
pEC50 |
- |
5 |
|
⤷ |
pEC50
6.7 – 7.1
[5]
Voltage:
-100.0 mV
|
Kir4.1
|
|
|
Rn |
Gating inhibitor (Intracellular H+) |
Antagonist |
6.0 – 6.1 |
pEC50 |
- |
5,10 |
|
⤷ |
pEC50
6.0 – 6.1
[5,10]
Voltage:
-100.0 mV
|
ASIC1
|
|
|
Hs |
Activator (Extracellular H+) |
- |
~5.1 – 6.8 |
pEC50 |
- |
|
|
⤷ |
pEC50
~6.2 – 6.8
(EC50 ~6.3x10-7 – 1.6x10-7 M)
ASIC1a
pEC50
~5.1 – 6.2
(EC50 ~8x10-6 – 6.3x10-7 M)
ASIC1b
|
ZAC
|
|
|
Hs |
Agonist |
Agonist |
5.6 |
pEC50 |
- |
8 |
|
⤷ |
pEC50
5.6
[8]
|
TRPV1
|
|
|
Hs |
Activator (extracellular H+) |
- |
5.4 |
pEC50 |
- |
|
|
⤷ |
pEC50
5.4
(EC50 3.98x10-6 M)
at 37°C
|
ASIC3
|
|
|
Hs |
Activator (Extracellular H+) |
- |
~3.5 – 6.7 |
pEC50 |
- |
|
|
⤷ |
pEC50
~6.2 – 6.7
(EC50 ~6.3x10-7 – 2x10-7 M)
transient component
pEC50
~3.5 – 4.3
(EC50 ~3.5x10-4 – 5x10-5 M)
sustained component
|
ASIC2
|
|
|
Hs |
Activator (Extracellular H+) |
- |
~4.1 – 5.0 |
pEC50 |
- |
|
|
⤷ |
pEC50
~4.1 – 5.0
(EC50 ~8x10-5 – 1x10-5 M)
|
TRPM7
|
|
|
Hs |
Activator (Extracellular H+) |
Potentiation |
4.5 |
pEC50 |
- |
4 |
|
⤷ |
pEC50
4.5
[4]
|
Kir1.1
|
|
|
Rn |
Gating inhibitor (Intracellular H+) |
Antagonist |
6.8 |
pIC50 |
- |
2,7,9 |
|
⤷ |
pIC50
6.8
[2,7,9]
Voltage:
-160.0 – -40.0 mV
|
TRPM5
|
|
|
Hs |
Channel blocker (Extracellular H+) |
- |
3.2 |
pIC50 |
- |
|
|
⤷ |
pIC50
3.2
(IC50 6.3x10-4 M)
|
glycine receptor α1 subunit
|
|
|
Hs |
Allosteric modulator (Extracellular H+) |
Inhibition |
- |
- |
- |
|
|
⤷ |
endogenous
|
TRPC6
|
|
|
Hs |
Channel blocker (Extracellular H+) |
- |
- |
- |
- |
|
|
⤷ |
|
TRPM2
|
|
|
Hs |
Channel blocker (extracellular H+) |
- |
- |
- |
- |
|
|
⤷ |
|
TRPM6
|
|
|
Hs |
Activator (extracellular H+) |
Potentiation |
- |
- |
- |
|
|
⤷ |
μM range
|