Synonyms: MEDI-3506 | MEDI3506
Compound class:
Antibody
Comment: Tozorakimab (MEDI3506) is a high-affinity anti-IL-33 monoclonal antibody. It inhibits IL-33-induced signalling to produce an anti-inflammatory effect [2]. Tozorakimab blocks the actions of both reduced IL-33 (IL-33red) and oxidized IL-33 (IL-33ox) metabolites through their respective downstream pathways (ST2 for IL-33red, RAGE/EGFR complex for IL-33ox) [1,3-4].
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Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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