pozelimab   Click here for help

GtoPdb Ligand ID: 12900

Synonyms: pozelimab-bbfg | REGN-3918 | REGN3918 | Veopoz®
Approved drug Immunopharmacology Ligand
pozelimab is an approved drug (FDA (2023))
Compound class: Antibody
Comment: Pozelimab (REGN-3918) targets the terminal complement component C5 [1]. It is designed to inhibit complement pathway activation and complement-mediated inflammatory tissue damage.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C5 Hs Antibody Binding 9.6 pKd - 1
⤷ pKd 9.6 (Kd 2.6x10-10 M) [1]
complement C5 Monkey Antibody Binding 8.1 pKd - 1
⤷ pKd 8.1 (Kd 8.55x10-9 M) [1]