Synonyms: compound 195 [WO2021113557A1] | NX5948
Compound class:
Synthetic organic
Comment: NX-5948 (Nurix Therapeutics) is an oral BTK protein degrader. It was designed as an alternative to BTK inhibitors for potential to treat B cell malignancies, including those that carry BTK mutations which confer resistance to existing BTK inhibitors [1-2]. In contrast to NX-2127 which degrades both BTK and IKZF3, NX-5948 selectively degrades BTK. We believe NX-5948 is compound 195 in patent WO2021113557A1 [3].
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Bioactivity Comments |
NX-5948 (compound 195) degrades BTK with a DC50 of 0.26 nM, and achieves ~75-80% reduction of BTK protein level in human cell assays (whole blood, splenocytes) [3]. |