civorebrutinib   Click here for help

GtoPdb Ligand ID: 12868

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: The structure for civorebrutinib was obtained from proposed INN list 129 (August 2023), where it is described as Bruton's tyrosine kinase inhibitor and antineoplastic agent. It is claimed in patent WO2019091440A1 (SINOMAB Bioscience) [1]. Review of SINOMAB's online pipeline page suggests that civorebrutinib is likely their lead BTK inhibitor SN1011.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 133.33
Molecular weight 463.92
XLogP 2.17
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=CC(=C1)OC2=CC=C(C=N2)Cl)C3=NN([C@@H]4CCC5(CC5)N(C4)C#N)C(=C3C(=O)N)N
Isomeric SMILES NC1=C(C(=NN1[C@H]2CN(C3(CC3)CC2)C#N)C4=CC=C(C=C4)OC5=NC=C(C=C5)Cl)C(=O)N
InChI InChI=1S/C23H22ClN7O2/c24-15-3-6-18(28-11-15)33-17-4-1-14(2-5-17)20-19(22(27)32)21(26)31(29-20)16-7-8-23(9-10-23)30(12-16)13-25/h1-6,11,16H,7-10,12,26H2,(H2,27,32)/t16-/m1/s1
InChI Key OSEITUBGGJDFBK-MRXNPFEDSA-N
Bioactivity Comments
In a small kinase screen, civorebrutinib was selective for BTK compared to LCK, SRC, LYN, ITK, TEC and EGFR [1]. In comparison ibrutinib was equipotent at all of these enzymes. Civorebrutinib inhibits B cell activation in vitro with an IC50 <10 nM.