Synonyms: Example 11 [WO2008024398A2] | XEN-1101 | XEN1101
Compound class:
Synthetic organic
Comment: Encukalner (XEN1101) is a clinical stage voltage-gated potassium channel (Kv7) activator [1], that was developed as a potential anti-epileptic drug, or for the treatment of major depressive disorder.
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Bioactivity Comments |
Activates Kv7.2/Kv7.3-mediated currents in PC-12 cells, using a Rb+ efflux assay (EC50 1-10 nM) [1]. |
Selectivity at ion channels | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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