magrolimab   Click here for help

GtoPdb Ligand ID: 12652

Synonyms: Hu5F9-G4
Immunopharmacology Ligand
Compound class: Antibody
Comment: Magrolimab (Hu5F9-G4) is a clinical lead, humanized monoclonal antibody, that binds to and blocks the function of cluster of differentiation 47 (CD47), a 'don't-eat-me' signal that is overexpressed by some cancer cells [1]. CD47-blockade disrupts the CD47-SIRPα anti-phagocytic checkpoint, which induces an immunostimulating effect that promotes macrophage-mediated phagocytosis of tumour cells [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10999 magrolimab
Synonyms Click here for help
Hu5F9-G4
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 916
Other databases
GtoPdb PubChem SID 483123200
Search PubMed clinical trials magrolimab
Search PubMed titles magrolimab
Search PubMed titles/abstracts magrolimab