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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Bromodomain (BRD)-containing kinases initiate acetylation-dependent assembly of transcriptional regulator complexes by binding to (or 'reading') acetyl-lysine marks on histone tails. The regulator complexes thus formed, control expression of sets of proteins which alter the cellular phenotype in specific ways. (BRD)-containing proteins are exciting targets for the development of novel small molecule therapeutics in the areas of cancer, inflammation and viral infection [1].
BRD1 (bromodomain containing 1)
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BRD2 (bromodomain containing 2)
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BRD3 (bromodomain containing 3)
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BRD4 (bromodomain containing 4)
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BRD7 (bromodomain containing 7)
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BRD8 (bromodomain containing 8)
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BRD9 (bromodomain containing 9)
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Database page citation:
Bromodomain kinase (BRDK) family. Accessed on 02/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=558.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.