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bromodomain containing 1

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Target not currently curated in GtoImmuPdb

Target id: 2724

Nomenclature: bromodomain containing 1

Abbreviated Name: BRD1

Family: Bromodomain kinase (BRDK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1058 22q13.33 BRD1 bromodomain containing 1
Mouse - 1189 15 E3 Brd1 bromodomain containing 1
Rat - 1058 7q34 Brd1 bromodomain containing 1
Previous and Unofficial Names Click here for help
BRPF2
Database Links Click here for help
Alphafold O95696 (Hs)
CATH/Gene3D 1.20.920.10, 3.30.40.10
ChEMBL Target CHEMBL2176774 (Hs)
Ensembl Gene ENSG00000100425 (Hs), ENSMUSG00000022387 (Mm), ENSRNOG00000004538 (Rn)
Entrez Gene 23774 (Hs), 223770 (Mm), 315210 (Rn)
Human Protein Atlas ENSG00000100425 (Hs)
KEGG Gene hsa:23774 (Hs), mmu:223770 (Mm), rno:315210 (Rn)
OMIM 604589 (Hs)
Pharos O95696 (Hs)
RefSeq Nucleotide NM_014577 (Hs), NM_001033274 (Mm), NM_001108103 (Rn)
RefSeq Protein NP_055392 (Hs), NP_001028446 (Mm), NP_001101573 (Rn)
UniProtKB O95696 (Hs)
Wikipedia BRD1 (Hs)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
NI-57 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Binding 7.0 pKd 2
⤷ pKd 7.0 (Kd 1.08x10-7 M) [2]
BAY-299 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.2 pIC50 1
⤷ pIC50 8.2 (IC50 6x10-9 M) [1]
Description: In a BROMOscan® assay.

References

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1. SGC. BAY-299 A probe for BRD1 and TAF1. Accessed on 05/04/2017. Modified on 04/08/2023. SGC, https://www.thesgc.org/chemical-probes/BAY-299

2. SGC. NI-57 – a chemical probe for BRPF bromodomains. Accessed on 15/07/2015. Modified on 04/08/2023. thesgc.org, https://www.thesgc.org/chemical-probes/NI-57

How to cite this page

Bromodomain kinase (BRDK) family: bromodomain containing 1. Last modified on 05/04/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2724.