Interleukin-2 receptor subunit γ | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

Top ▲

Interleukin-2 receptor subunit γ

  Target has curated data in GtoImmuPdb

Target id: 2303

Nomenclature: Interleukin-2 receptor subunit γ

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-2 receptor
Interleukin-4 receptor type I
Interleukin-7 receptor
Interleukin-9 receptor
Interleukin-15 receptor
Interleukin-21 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 369 Xq13.1 IL2RG interleukin 2 receptor subunit gamma
Mouse 1 369 X 43.9 cM Il2rg interleukin 2 receptor
Rat - - Xq31 Il2rg interleukin 2 receptor subunit gamma
Previous and Unofficial Names
CD132 | cytokine receptor common subunit gamma | IL-2RG | interleukin 2 receptor, gamma | interleukin 2 receptor, gamma chain | interleukin 2 receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
IL2RG is a common signal transducing subunit shared by the receptors for several different cytokines, namely the IL-2 receptor heterotrimer, the IL-4 receptor type I, the IL-7 receptor, the IL-9 receptor, the IL-15 receptor and the IL-21 receptor.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 8 GO processes, IEA only
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0035723 interleukin-15-mediated signaling pathway TAS
GO:0038113 interleukin-9-mediated signaling pathway TAS
GO:0038114 interleukin-21-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0004896 cytokine receptor activity IEA
GO:0035771 interleukin-4-mediated signaling pathway IEA
GO:0038110 interleukin-2-mediated signaling pathway IEA
GO:0038111 interleukin-7-mediated signaling pathway IEA

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit γ. Last modified on 10/04/2017. Accessed on 19/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2303.