Interleukin-2 receptor subunit γ | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-2 receptor subunit γ

  Target has curated data in GtoImmuPdb

Target id: 2303

Nomenclature: Interleukin-2 receptor subunit γ

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-2 receptor
Interleukin-4 receptor type I
Interleukin-7 receptor
Interleukin-9 receptor
Interleukin-15 receptor
Interleukin-21 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 369 Xq13.1 IL2RG interleukin 2 receptor subunit gamma
Mouse 1 369 X 43.9 cM Il2rg interleukin 2 receptor, gamma chain
Rat - - Xq31 Il2rg interleukin 2 receptor subunit gamma
Previous and Unofficial Names
CD132 | cytokine receptor common subunit gamma | IL-2RG | interleukin 2 receptor, gamma | interleukin 2 receptor, gamma chain | interleukin 2 receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
IL2RG is a common signal transducing subunit shared by the receptors for several different cytokines, namely the IL-2 receptor heterotrimer, the IL-4 receptor type I, the IL-7 receptor, the IL-9 receptor, the IL-15 receptor and the IL-21 receptor.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 9 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0035723 interleukin-15-mediated signaling pathway IMP
GO:0038110 interleukin-2-mediated signaling pathway TAS
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:0038113 interleukin-9-mediated signaling pathway TAS
GO:0038114 interleukin-21-mediated signaling pathway TAS
GO:0042010 interleukin-15 receptor activity IDA
click arrow to show/hide IEA associations
GO:0035771 interleukin-4-mediated signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050766 positive regulation of phagocytosis IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045579 positive regulation of B cell differentiation IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0033089 positive regulation of T cell differentiation in thymus IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0045621 positive regulation of lymphocyte differentiation IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0033089 positive regulation of T cell differentiation in thymus IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0033089 positive regulation of T cell differentiation in thymus IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0045621 positive regulation of lymphocyte differentiation IMP
Immuno Process:  Immune system development
GO Annotations:  Associated to 4 GO processes
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0033089 positive regulation of T cell differentiation in thymus IMP
GO:0045579 positive regulation of B cell differentiation IMP
GO:0045621 positive regulation of lymphocyte differentiation IMP
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
GO:0033089 positive regulation of T cell differentiation in thymus IMP

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit γ. Last modified on 10/04/2017. Accessed on 04/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2303.