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Quaternary Structure: Subunits |
Interleukin-2 receptor subunit α (Ligand-binding subunit) |
Interleukin-2 receptor subunit β (Ligand-binding subunit) |
Interleukin-2 receptor subunit γ (Other subunit) |
Natural/Endogenous Ligands |
IL-2 {Sp: Human} |
IL-1 receptor antagonist {Sp: Human} |
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Immunopharmacology Comments |
The IL-2 receptor is a heterotrimeric complex of the interleukin-2 receptor subunits α, β and γ. The α and β subunits can bind IL-2, and signalling is generated by heterodimerization of the β and γ subunits. |
1. Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW et al.. (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem, 271 (48): 30517-23. [PMID:8940020]
2. Tilley JW, Chen L, Fry DC, Emerson SD, Powers GD, Biondi D, Varnell T, Trilles R, Guthrie R, Mennona F, Kaplan G, LeMahieu RA, Carson M, Han RJ, Liu CM, Palermo R, Ju G. (1997) Identification of a small molecule inhibitor of the IL-2/IL-2R alpha receptor interaction which binds to IL-2. J Am Chem Soc, 119 (32): 7589-7590. DOI: 10.1021/ja970702x
IL-2 receptor family: Interleukin-2 receptor. Last modified on 17/07/2017. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2297.