IL-2 receptor family | Catalytic receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

IL-2 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-2 receptor family consists of one or more ligand-selective subunits, and a common γ chain (γc): IL2RG, P31785), though IL-4 and IL-7 receptors can form complexes with other receptor chains. Receptors of this family associate with Jak1 and Jak3, primarily activating Stat5, although certain family members can also activate Stat1, Stat3, or Stat6. Ro264550 has been described as a selective IL-2 receptor antagonist, which binds to IL-2 [4].

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

Complexes

Interleukin-2 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-4 receptor type I C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-4 receptor type II C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-7 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-9 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-15 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-21 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Thymic stromal lymphopoietin receptor C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

Interleukin 13 receptor, α2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1701
Nomenclature	Interleukin 13 receptor, α2
Previous and unofficial names	interleukin 13 receptor \| cancer/testis antigen 19 \| CD213a2 \| CT19 \| IL13BP \| IL-13RA2 \| IL-13 receptor alpha-2 \| IL-13R subunit alpha-2
Genes	IL13RA2 (Hs), Il13ra2 (Mm), Il13ra2 (Rn)
Ensembl ID	ENSG00000123496 (Hs), ENSMUSG00000031289 (Mm), ENSRNOG00000032973 (Rn)
UniProtKB AC	Q14627 (Hs), O88786 (Mm), Q8VHK6 (Rn)
Comment	Decoy receptor that binds IL-13 (IL13, P35225) as a monomer.

Interleukin-2 receptor subunit α C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-2 receptor subunit β C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-2 receptor subunit γ C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-4 receptor subunit α C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-7 receptor subunit α C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 9 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-13 receptor subunit α1 C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-15 receptor subunit α C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 21 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Cytokine receptor-like factor 2 C Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW et al.. (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem, 271 (48): 30517-23. [PMID:8940020]

2. Martin JH, Huang TT, Fairhurst JL, Papadopoulos NJ. (2009) Cytokine specific immunoglobulin for use in diagnosis, prevention and treatment ,of cell proliferative, inflammatory, allergic, respiratory, autoimmune and arthritic disorders. Patent number: US7608693. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/10/2006. Publication date: 27/10/2009.

3. Queen CL, Schneider WP, Selick HE. (1997) Genetic engineering; complementarity zones. Patent number: US5693761. Assignee: Protein Design Labs, Inc.. Priority date: 28/12/1988. Publication date: 02/12/1997.

4. Tilley JW, Chen L, Fry DC, Emerson SD, Powers GD, Biondi D, Varnell T, Trilles R, Guthrie R, Mennona F, Kaplan G, LeMahieu RA, Carson M, Han RJ, Liu CM, Palermo R, Ju G. (1997) Identification of a small molecule inhibitor of the IL-2/IL-2R alpha receptor interaction which binds to IL-2. J Am Chem Soc, 119 (32): 7589-7590. DOI: 10.1021/ja970702x

5. Zhu X, Marcus WD, Xu W, Lee HI, Han K, Egan JO, Yovandich JL, Rhode PR, Wong HC. (2009) Novel human interleukin-15 agonists. J Immunol, 183 (6): 3598-607. [PMID:19710453]

How to cite this family page

Database page citation:

IL-2 receptor family. Accessed on 14/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=305.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.