Quaternary Structure: Subunits

Interleukin-2 receptor subunit β (Ligand-binding subunit)

Interleukin-15 receptor subunit α (Ligand-binding subunit)

Interleukin-2 receptor subunit γ (Other subunit)

Natural/Endogenous Ligands
IL-15 {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference ALT-803 Hs Agonist 10.8 pEC50 2 ⤷ pEC50 10.8 (EC50 1.56x10-11 M) [2] Description: Evaluated using an IL-15 dependent 32Dβ cell proliferation assay. ALT-803 Hs Agonist ~12.3 pIC50 3 ⤷ pIC50 ~12.3 (IC50 ~5x10-13 M) [3] Description: Binding of rhIL-15N72D to hIL-15R in vitro. IL-15 {Sp: Human} Hs Agonist 11.4 pIC50 3 ⤷ pIC50 11.4 (IC50 3.8x10-12 M) [3] Description: Binding of rhIL-15 in vitro, using cells expressing the intact hIL-15Rα-hIL-15Rβ-hγ complex.

Immunopharmacology Comments

The functional IL-15 receptor is a heteromer consisting of the high affinity ligand binding interleukin-15 receptor subunit α (IL15RA) and common IL-2-γ and -β signal transducing subunits (IL2RG and IL2RB) [1].