Interleukin-2 receptor subunit β | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-2 receptor subunit β

  Target has curated data in GtoImmuPdb

Target id: 1696

Nomenclature: Interleukin-2 receptor subunit β

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-2 receptor
Interleukin-15 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 551 22q12.3 IL2RB interleukin 2 receptor subunit beta
Mouse 1 539 Il2rb interleukin 2 receptor, beta chain
Rat 1 537 Il2rb interleukin 2 receptor subunit beta
Previous and Unofficial Names
CD122 | IL15RB | interleukin 15 receptor, beta | high affinity IL-2 receptor subunit beta | IL-2R subunit beta | IL-15 receptor beta chain | IL-2/15Rbeta | interleukin 2 receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
IL2RB is a ligand binding component of the IL-2R and is required to elevate ligand affinity. It also a component of the IL-15R.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0004911 interleukin-2 receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0035723 interleukin-15-mediated signaling pathway IMP
GO:0038110 interleukin-2-mediated signaling pathway TAS
GO:0042010 interleukin-15 receptor activity IDA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050766 positive regulation of phagocytosis IMP

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit β. Last modified on 28/03/2017. Accessed on 22/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY,