Syk inhibitor II   Click here for help

GtoPdb Ligand ID: 6047

Synonyms: K00592a
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: This is compound 3 in [2] and compound 9a in the original article by Hisamichi et al. (2005) [4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 7
Topological polar surface area 118.95
Molecular weight 340.13
XLogP 1.51
No. Lipinski's rules broken 0
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Canonical SMILES NCCNc1ncc(c(n1)Nc1cccc(c1)C(F)(F)F)C(=O)N
Isomeric SMILES NCCNc1ncc(c(n1)Nc1cccc(c1)C(F)(F)F)C(=O)N
InChI InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
checkpoint kinase 2 CHK2/CHK2 Hs Inhibitor Inhibition 11.5 15.0 2.0
protein kinase D3 nd/PKCnu(PRKD3) Hs Inhibitor Inhibition 13.5
spleen associated tyrosine kinase Syk/SYK Hs Inhibitor Inhibition 15.6 6.0 0.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 22.6 45.0 13.0
mitogen-activated protein kinase kinase kinase kinase 2 GCK/GCK(MAP4K2) Hs Inhibitor Inhibition 29.8 13.0 0.0
protein kinase D1 PKCμ/PKCmu(PRKD1) Hs Inhibitor Inhibition 30.3 35.0 8.0
fms related receptor tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 32.3 50.0 5.0
testis specific serine kinase 1B TSSK1/STK22D(TSSK1) Hs Inhibitor Inhibition 32.9 56.0 10.0
protein kinase D2 PKD2/PKD2(PRKD2) Hs Inhibitor Inhibition 33.0 85.0 29.0
FER tyrosine kinase Fer/FER Hs Inhibitor Inhibition 37.5 102.0 47.0
Displaying the top 10 targets  View all targets in screen »