ChEMBL ligand: CHEMBL471901
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] There should be some charts here, you may need to enable JavaScript!
Lysyl-tRNA synthetase in Human [ChEMBL: CHEMBL5575] [UniProtKB: Q15046] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
ChEMBL	Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay	B	6.34	pIC50	456	nM	IC50	J Med Chem (2020) 63: 6784-6801 [PMID:32433887]
ChEMBL	Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubated for 15 mins followed by ATP addition and measured after 2 hrs by ADP-glo luminescence assay	B	6.36	pIC50	432	nM	IC50	J Med Chem (2020) 63: 6784-6801 [PMID:32433887]
Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046]
ChEMBL	Inhibition of human Syk	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem (2008) 16: 7347-7357 [PMID:18585046]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of SYK	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6231-6235 [PMID:18938080]
ChEMBL	Inhibition of recombinant Syk	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1944-1949 [PMID:19254842]
ChEMBL	Inhibition of spleen tyrosine kinase (unknown origin)	B	7.39	pIC50	41	nM	IC50	Eur J Med Chem (2013) 67: 434-446 [PMID:23917087]
GtoPdb	-	-	7.39	pIC50	41	nM	IC50	Bioorg Med Chem (2005) 13: 4936-51 [PMID:15990316]
ChEMBL	Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay	B	8.15	pIC50	7	nM	IC50	J Med Chem (2020) 63: 6784-6801 [PMID:32433887]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
GtoPdb	-	-	4.95	pIC50	11200	nM	IC50	Bioorg Med Chem (2005) 13: 4936-51 [PMID:15990316]
ChEMBL	Inhibition of human ZAP70	B	4.95	pIC50	11200	nM	IC50	Bioorg Med Chem (2008) 16: 7347-7357 [PMID:18585046]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]