PDGF receptor tyrosine kinase inhibitor IV   Click here for help

GtoPdb Ligand ID: 6020

Synonyms: JNJ-10198409
Compound class: Synthetic organic
Comment: This is compound 17 in [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 59.17
Molecular weight 325.12
XLogP 3.69
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc2c(cc1OC)Cc1c2[nH]nc1Nc1cccc(c1)F
Isomeric SMILES COc1cc2c(cc1OC)Cc1c2[nH]nc1Nc1cccc(c1)F
InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 15.1 6.0 3.0
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 20.0 1.0 0.0
ABL proto-oncogene 2, non-receptor tyrosine kinase Arg/ABL2(ARG) Hs Inhibitor Inhibition 21.4 12.0 1.0
LIM domain kinase 1 LIMK1/LIMK1 Hs Inhibitor Inhibition 23.3 13.0 2.0
fms related receptor tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 25.0 47.0 5.0
KIT proto-oncogene, receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 27.9 0.0 0.0
platelet derived growth factor receptor alpha PDGFRα/PDGFRa Hs Inhibitor Inhibition 33.4 2.0 1.0
salt inducible kinase 2 nd/SIK2 Hs Inhibitor Inhibition 38.6
Bruton tyrosine kinase BTK/BTK Hs Inhibitor Inhibition 40.8 22.0 4.0
LCK proto-oncogene, Src family tyrosine kinase Lck/LCK Hs Inhibitor Inhibition 41.3 24.0 3.0
Displaying the top 10 targets  View all targets in screen »