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ChEMBL ligand: CHEMBL120077 (JNJ-10198409) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibitory activity against Casein Kinase 2 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibitory activity against CDK1 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk1 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibitory activity against CDK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk2 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
ChEMBL | Inhibitory activity against CDK4 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk4 | B | 4 | pIC50 | >100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
ChEMBL | Inhibitory activity against CDK7 | B | 4.25 | pIC50 | 56700 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk7 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibitory activity against EGFR | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of human EGFR at 10000 nM | B | 4 | pIC50 | >100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibitory activity against bFGFR1 | B | 4.34 | pIC50 | 45800 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of bFGFR1 | B | 4.34 | pIC50 | 45800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibitory activity against FAK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibitory activity against IRK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibitory activity against MAPK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
ChEMBL | Inhibitory activity against PDGFRalpha | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of PDGFRalpha | B | 7.35 | pIC50 | 45 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
ChEMBL | Inhibitory activity against PDGFRbeta kinase | B | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of PDGFRbeta | B | 8.38 | pIC50 | 4.2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2005) 48: 8163-73 [PMID:16366598] |
ChEMBL | Antiproliferative activity against PDGF-BB stimulated HCASMC | F | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibitory activity against HER2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of HER2 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibitory activity against c-ABL | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of cAbl | B | 7.66 | pIC50 | 22 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibitory activity against FYN | B | 6.42 | pIC50 | 378 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Fyn | B | 6.42 | pIC50 | 378 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibitory activity against LCK | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Lck | B | 7 | pIC50 | 100 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibitory activity against c-SRC | B | 6.73 | pIC50 | 185 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of c-Src | B | 6.73 | pIC50 | 185 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]