elotuzumab   Click here for help

GtoPdb Ligand ID: 8361

Synonyms: BMS-901608 | Empliciti® | HuLuc63
Approved drug Immunopharmacology Ligand
elotuzumab is an approved drug (FDA (2015), EMA (2016))
Compound class: Antibody
Comment: Elotuzumab is a humanized IgG1 antibody targeting CS1 (SLAMF7) [1-2].
Peptide sequences for elotuzumab are available from its IMGT/mAb-DB record.
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1. Hsi ED, Steinle R, Balasa B, Szmania S, Draksharapu A, Shum BP, Huseni M, Powers D, Nanisetti A, Zhang Y et al.. (2008)
CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma.
Clin Cancer Res, 14 (9): 2775-84. [PMID:18451245]
2. Tai YT, Dillon M, Song W, Leiba M, Li XF, Burger P, Lee AI, Podar K, Hideshima T, Rice AG et al.. (2008)
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
Blood, 112 (4): 1329-37. [PMID:17906076]
3. van Rhee F, Szmania SM, Dillon M, van Abbema AM, Li X, Stone MK, Garg TK, Shi J, Moreno-Bost AM, Yun R et al.. (2009)
Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma.
Mol Cancer Ther, 8 (9): 2616-24. [PMID:19723891]
4. Veillette A, Guo H. (2013)
CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma.
Crit Rev Oncol Hematol, 88 (1): 168-77. [PMID:23731618]
5. Williams M, Tso JY, Landolfi NF, Powers DB, Liu G. (2010)
Therapeutic use of anti-CS1 antibodies.
Patent number: US7709610. Assignee: Facet Biotech Corporation. Priority date: 28/05/2003. Publication date: 04/05/2010.