elotuzumab   Click here for help

GtoPdb Ligand ID: 8361

Synonyms: BMS-901608 | Empliciti® | HuLuc63
Approved drug Immunopharmacology Ligand
elotuzumab is an approved drug (FDA (2015), EMA (2016))
Compound class: Antibody
Comment: Elotuzumab is a humanized IgG1 antibody targeting CS1 (SLAMF7) [1-2].
Peptide sequences for elotuzumab are available from its IMGT/mAb-DB record.
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Immunopharmacology Comments
Elotuzumab targets the CS1 surface glycoprotein that is highly expressed in primary tumor cells from the majority of MM patients [2].
Immunopharmacology Disease
Disease X-Refs Comment References
Systemic lupus erythematosus Disease Ontology: DOID:9074
OMIM: 152700
Orphanet: ORPHA536
CS1 expression is elevated in patients with SLE suggesting that CS1-targeted inhibition may be effective in this condition.
Multiple myeloma Disease Ontology: DOID:9538
OMIM: 254500
Approved drug for MM.