aspirin   Click here for help

GtoPdb Ligand ID: 4139

Synonyms: Acetophen® | acetylsalicylic acid | Aspirin®
Approved drug PDB Ligand Immunopharmacology Ligand
aspirin is an approved drug (FDA (no history prior to 1965))
Compound class: Synthetic organic
Comment: Aspirin is the prototypical cyclooxygenase inhibitor and inhibits the biosynthesis of prostaglandins. Aspirin acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: aspirin

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 63.6
Molecular weight 180.04
XLogP 1.42
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES CC(=O)Oc1ccccc1C(=O)O
Isomeric SMILES CC(=O)Oc1ccccc1C(=O)O
InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChI Key BSYNRYMUTXBXSQ-UHFFFAOYSA-N
References
1. Chowdhury MA, Abdellatif KR, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE. (2009)
Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorg Med Chem Lett, 19 (24): 6855-61. [PMID:19884005]
2. Takahashi T, Miyazawa M. (2012)
N-Caffeoyl serotonin as selective COX-2 inhibitor.
Bioorg Med Chem Lett, 22 (7): 2494-6. [PMID:22386242]
3. Voilley N, de Weille J, Mamet J, Lazdunski M. (2001)
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
J Neurosci, 21 (20): 8026-33. [PMID:11588175]