aspirin   Click here for help

GtoPdb Ligand ID: 4139

Synonyms: Acetophen® | acetylsalicylic acid | Aspirin®
Approved drug PDB Ligand Immunopharmacology Ligand
aspirin is an approved drug (FDA (no history prior to 1965))
Compound class: Synthetic organic
Comment: Aspirin is the prototypical cyclooxygenase inhibitor and inhibits the biosynthesis of prostaglandins. Aspirin acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 63.6
Molecular weight 180.04
XLogP 1.42
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC(=O)Oc1ccccc1C(=O)O
Isomeric SMILES CC(=O)Oc1ccccc1C(=O)O
InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChI Key BSYNRYMUTXBXSQ-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Aspirin is used to treat pain, and reduce fever or inflammation. It is also used as a preventative treatment for heart attacks, strokes, and chest pain (angina).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The analgesic, antipyretic, and anti-inflammatory effects of aspirin are due to direct and irreversible inhibition of both cyclooxygenases (COX-1 and COX-2) leading to decreased formation of the precursors of prostaglandins and thromboxanes from arachidonic acid. The main mechanism accounting for platelet aggregation-inhibition by aspirin is irreversible acetylation and inactivation of platelet cyclooxygenase, which blocks the formation of the aggregating agent thromboxane A2.