aspirin [Ligand Id: 4139] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL25 (8-hour bayer, Acetosalic Acid, Acetylsalic acid, Acetyl salicylate, Acetylsalicylic acid, Acetylsalicylic Acid, Acetylsalicylic acid (who-ip), Acetylsalicylicum acidum, Acidum acetylsalicylicum, Acidum acetylsalicylicum (who-ip), Alka rapid, Anadin all night, Angettes 75, Aspirin, Aspro clr, BAY1019036, Bayer extra strength aspirin for migraine pain, Benzoic acid, 2-(acetyloxy)-, Danamep, Disprin cv, Disprin direct, Durlaza, Ecotrin, Enprin, Equi-Prin, Gencardia, Levius, Max strgh aspro clr, Measurin, Micropirin ec, NSC-27223, NSC-406186, Nu-seals 300, Nu-seals 600, Nu-seals 75, Nu-seals cardio 75, Paynocil, Platet, Platet 300, Postmi 300, Postmi 75, Salicylic Acid Acetate, Vazalore) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 4.21 | pKi | 62000 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
| GtoPdb | - | - | 3.25 | pIC50 | 560100 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6855-61 [PMID:19884005] |
| ChEMBL | Inhibition of COX1 | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (2008) 51: 2400-2411 [PMID:18363350] |
| ChEMBL | Inhibition of COX1 | B | 4 | pIC50 | >100000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 353-357 [PMID:24900317] |
| ChEMBL | Inhibition of COX1 by radioimmunoassay method | B | 4.94 | pIC50 | 11400 | nM | IC50 | J Nat Prod (2007) 70: 795-801 [PMID:17480099] |
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 5.38 | pIC50 | 4192 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Inhibition of COX1 (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228] |
| Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664] | ||||||||
| ChEMBL | Inhibition of bovine COX-1 by enzyme immuno assay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6855-6861 [PMID:19884005] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibition of ovine COX1 | B | 4 | pIC50 | 100000 | nM | IC50 | Bioorg Med Chem (2007) 15: 1014-1021 [PMID:17079150] |
| ChEMBL | Inhibition of ovine COX1 by measuring PGE2 | B | 4.05 | pIC50 | 90000 | nM | IC50 | Bioorg Med Chem (2007) 15: 6109-6118 [PMID:17604631] |
| ChEMBL | Inhibitory concentration in DMSO with purified ovine Prostaglandin G/H synthase 1 (COX-1). | B | 4.9 | pIC50 | 12500 | nM | IC50 | J Med Chem (1998) 41: 4800-4818 [PMID:9822550] |
| ChEMBL | Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917] |
| ChEMBL | Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay | B | 5.21 | pIC50 | 6120 | nM | IC50 | Eur J Med Chem (2019) 180: 86-98 [PMID:31301566] |
| ChEMBL | Inhibition of sheep COX1-mediated PGE2 production after 2 mins by liquid scintillation counting | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Nat Prod (2010) 73: 1763-1766 [PMID:20961090] |
| ChEMBL | Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA | B | 6.39 | pIC50 | 411 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6922-6925 [PMID:19880317] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259] |
| ChEMBL | Inhibition of ovine COX-1 by enzyme immuno assay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2154-2159 [PMID:22361134] |
| ChEMBL | Inhibition of ovine COX1 | B | 6.46 | pIC50 | 350 | nM | IC50 | Eur J Med Chem (2009) 44: 1278-1287 [PMID:18835505] |
| ChEMBL | Inhibition of ovine COX1 | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6138-6141 [PMID:18945614] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2007) 15: 6796-6801 [PMID:17764958] |
| ChEMBL | In vitro inhibition of ovine prostaglandin G/H synthase 1 | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2004) 47: 6108-6111 [PMID:15537365] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immunoassay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 3302-3308 [PMID:18096394] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 1948-1956 [PMID:18023187] |
| ChEMBL | Inhibitory activity against ovine COX1 | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2006) 49: 1668-1683 [PMID:16509583] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immunoassay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immunoassay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3014-3018 [PMID:19419861] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2007) 15: 4767-4774 [PMID:17509888] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immunoassay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072] |
| ChEMBL | Inhibition of sheep COX1 by enzyme immunoassay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432] |
| ChEMBL | Inhibition of ovine COX1 by enzyme immuno assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358] |
| ChEMBL | Inhibition of ovine COX1 | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2012) 55: 688-696 [PMID:22148253] |
| ChEMBL | In vitro inhibitory concentration against COX-1 enzyme | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2005) 48: 4061-4067 [PMID:15943479] |
| ChEMBL | Inhibition of ovine COX-1 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2016) 118: 250-258 [PMID:27131067] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 4.28 | pKi | 52000 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
| ChEMBL | Inhibition of human recombinant COX2 by measuring PGE2 | B | 4 | pIC50 | 100000 | nM | IC50 | Bioorg Med Chem (2007) 15: 6109-6118 [PMID:17604631] |
| ChEMBL | Inhibitory concentration in DMSO with purified human Prostaglandin G/H synthase 2 (COX-2) | B | 4.2 | pIC50 | 62500 | nM | IC50 | J Med Chem (1998) 41: 4800-4818 [PMID:9822550] |
| ChEMBL | Inhibition of COX2 by radioimmunoassay method | B | 4.7 | pIC50 | 19800 | nM | IC50 | J Nat Prod (2007) 70: 795-801 [PMID:17480099] |
| ChEMBL | Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay | B | 4.91 | pIC50 | 12360 | nM | IC50 | Eur J Med Chem (2019) 180: 86-98 [PMID:31301566] |
| ChEMBL | Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917] |
| ChEMBL | Inhibition of human recombinant COX-2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2154-2159 [PMID:22361134] |
| ChEMBL | Inhibition of human recombinant COX2 | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2012) 55: 688-696 [PMID:22148253] |
| ChEMBL | Inhibition of human recombinant COX2 | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247] |
| ChEMBL | Inhibition of COX2 (unknown origin) | B | 5.62 | pIC50 | 2400 | nM | IC50 | ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228] |
| ChEMBL | Inhibition of human recombinant COX-2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6855-6861 [PMID:19884005] |
| ChEMBL | Inhibition of human recombinant COX2 by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994] |
| ChEMBL | Inhibition of human recombinant COX2 by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072] |
| ChEMBL | Inhibition of human COX2 by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432] |
| GtoPdb | - | - | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2494-6 [PMID:22386242] |
| Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208] | ||||||||
| ChEMBL | Inhibition of ovine COX2 | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2007) 15: 1014-1021 [PMID:17079150] |
| ChEMBL | Inhibition of sheep COX2-mediated PGE2 production after 2 mins by liquid scintillation counting | B | 4.86 | pIC50 | 13900 | nM | IC50 | J Nat Prod (2010) 73: 1763-1766 [PMID:20961090] |
| ChEMBL | Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA | B | 5.6 | pIC50 | 2530 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6922-6925 [PMID:19880317] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2007) 15: 4767-4774 [PMID:17509888] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2007) 15: 6796-6801 [PMID:17764958] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2008) 16: 1948-1956 [PMID:18023187] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2008) 16: 3302-3308 [PMID:18096394] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259] |
| ChEMBL | Inhibition of ovine COX2 | B | 5.62 | pIC50 | 2400 | nM | IC50 | Eur J Med Chem (2009) 44: 1278-1287 [PMID:18835505] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6138-6141 [PMID:18945614] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3014-3018 [PMID:19419861] |
| ChEMBL | Inhibition of ovine COX2 by enzyme immuno assay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358] |
| ChEMBL | Inhibition of ovine COX-2 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Eur J Med Chem (2016) 118: 250-258 [PMID:27131067] |
| ChEMBL | In vitro inhibition of ovine prostaglandin G/H synthase 2 | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2004) 47: 6108-6111 [PMID:15537365] |
| ChEMBL | Inhibition of Ovine COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2893-2899 [PMID:27158139] |
| ChEMBL | In vitro inhibitory concentration against COX-2 enzyme | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2005) 48: 4061-4067 [PMID:15943479] |
| ChEMBL | Inhibitory activity against ovine COX2 | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2006) 49: 1668-1683 [PMID:16509583] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917] |
| Gamma-glutamyltranspeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5696] [UniProtKB: P19440] | ||||||||
| ChEMBL | Inhibition of gamma-glutamyltranspeptidase by colorimetric assay | B | 4.44 | pIC50 | 36000 | nM | IC50 | Eur J Med Chem (2009) 44: 197-202 [PMID:18400337] |
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] | ||||||||
| ChEMBL | Inhibition of collagen-induced platelet aggregation | F | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1995) 38: 34-41 [PMID:7837237] |
| ChEMBL | Inhibition of arachidonic acid-induced platelet aggregation | F | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (1995) 38: 34-41 [PMID:7837237] |
| Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] | ||||||||
| ChEMBL | Inhibition of NAPRT (unknown origin) | B | 9.3 | pKi | 0.5 | nM | Ki | WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (null) |
| ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] | ||||||||
| GtoPdb | - | - | 4 | pIC50 | 92000 | nM | IC50 | J Neurosci (2001) 21: 8026-33 [PMID:11588175] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
