ChEMBL ligand: CHEMBL25 (8-hour bayer, Acetosalic Acid, Acetylsalic acid, Acetyl salicylate, Acetylsalicylic acid, Acetylsalicylic Acid, Acetylsalicylic acid (who-ip), Acetylsalicylicum acidum, Acidum acetylsalicylicum, Acidum acetylsalicylicum (who-ip), Alka rapid, Anadin all night, Angettes 75, Aspirin, Aspro clr, BAY1019036, Bayer extra strength aspirin for migraine pain, Benzoic acid, 2-(acetyloxy)-, Danamep, Disprin cv, Disprin direct, Durlaza, Ecotrin, Enprin, Equi-Prin, Gencardia, Levius, Max strgh aspro clr, Measurin, Micropirin ec, NSC-27223, NSC-406186, Nu-seals 300, Nu-seals 600, Nu-seals 75, Nu-seals cardio 75, Paynocil, Platet, Platet 300, Postmi 300, Postmi 75, Salicylic Acid Acetate, Vazalore)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Bovine [ChEMBL: CHEMBL2860] [UniProtKB: O62664] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
Gamma-glutamyltranspeptidase 1 in Human [ChEMBL: CHEMBL5696] [UniProtKB: P19440] There should be some charts here, you may need to enable JavaScript!
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] There should be some charts here, you may need to enable JavaScript!
Nicotinate phosphoribosyltransferase in Human [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] There should be some charts here, you may need to enable JavaScript!
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method	B	4.21	pKi	62000	nM	Ki	J Med Chem (2013) 56: 8377-8388 [PMID:24088053]
GtoPdb	-	-	3.25	pIC50	560100	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6855-61 [PMID:19884005]
ChEMBL	Inhibition of COX1	B	4	pIC50	100000	nM	IC50	J Med Chem (2008) 51: 2400-2411 [PMID:18363350]
ChEMBL	Inhibition of COX1	B	4	pIC50	>100000	nM	IC50	ACS Med Chem Lett (2011) 2: 353-357 [PMID:24900317]
ChEMBL	Inhibition of COX1 by radioimmunoassay method	B	4.94	pIC50	11400	nM	IC50	J Nat Prod (2007) 70: 795-801 [PMID:17480099]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	5.38	pIC50	4192	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of COX1 (unknown origin)	B	6.46	pIC50	350	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL	Inhibition of bovine COX-1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6855-6861 [PMID:19884005]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1	B	3.52	pIC50	300000	nM	IC50	Eur J Med Chem (2019) 179: 272-309 [PMID:31255927]
ChEMBL	Inhibition of ovine COX1	B	4	pIC50	100000	nM	IC50	Bioorg Med Chem (2007) 15: 1014-1021 [PMID:17079150]
ChEMBL	Inhibition of ovine COX1 by measuring PGE2	B	4.05	pIC50	90000	nM	IC50	Bioorg Med Chem (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL	Inhibitory concentration in DMSO with purified ovine Prostaglandin G/H synthase 1 (COX-1).	B	4.9	pIC50	12500	nM	IC50	J Med Chem (1998) 41: 4800-4818 [PMID:9822550]
ChEMBL	Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	5.21	pIC50	6120	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Inhibition of sheep COX1-mediated PGE2 production after 2 mins by liquid scintillation counting	B	5.35	pIC50	4500	nM	IC50	J Nat Prod (2010) 73: 1763-1766 [PMID:20961090]
ChEMBL	Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA	B	6.39	pIC50	411	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL	Inhibition of ovine COX-1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL	Inhibition of ovine COX1	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibitory activity against ovine COX1	B	6.46	pIC50	350	nM	IC50	J Med Chem (2006) 49: 1668-1683 [PMID:16509583]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL	In vitro inhibition of ovine prostaglandin G/H synthase 1	B	6.46	pIC50	350	nM	IC50	J Med Chem (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL	Inhibition of ovine COX1	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2009) 44: 1278-1287 [PMID:18835505]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL	Inhibition of sheep COX1 by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX1	B	6.52	pIC50	300	nM	IC50	J Med Chem (2012) 55: 688-696 [PMID:22148253]
ChEMBL	Inhibition of ovine COX-1 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2016) 118: 250-258 [PMID:27131067]
ChEMBL	In vitro inhibitory concentration against COX-1 enzyme	B	6.52	pIC50	300	nM	IC50	J Med Chem (2005) 48: 4061-4067 [PMID:15943479]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method	B	4.28	pKi	52000	nM	Ki	J Med Chem (2013) 56: 8377-8388 [PMID:24088053]
ChEMBL	Inhibition of human recombinant COX2 by measuring PGE2	B	4	pIC50	100000	nM	IC50	Bioorg Med Chem (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL	Inhibitory concentration in DMSO with purified human Prostaglandin G/H synthase 2 (COX-2)	B	4.2	pIC50	62500	nM	IC50	J Med Chem (1998) 41: 4800-4818 [PMID:9822550]
ChEMBL	Inhibition of COX2 by radioimmunoassay method	B	4.7	pIC50	19800	nM	IC50	J Nat Prod (2007) 70: 795-801 [PMID:17480099]
ChEMBL	Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	4.91	pIC50	12360	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL	Inhibition of human recombinant COX2	B	5.62	pIC50	2400	nM	IC50	J Med Chem (2012) 55: 688-696 [PMID:22148253]
ChEMBL	Inhibition of human recombinant COX2	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of COX2 (unknown origin)	B	5.62	pIC50	2400	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6855-6861 [PMID:19884005]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of human COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432]
GtoPdb	-	-	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2494-6 [PMID:22386242]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX2	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2007) 15: 1014-1021 [PMID:17079150]
ChEMBL	Inhibition of sheep COX2-mediated PGE2 production after 2 mins by liquid scintillation counting	B	4.86	pIC50	13900	nM	IC50	J Nat Prod (2010) 73: 1763-1766 [PMID:20961090]
ChEMBL	Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA	B	5.6	pIC50	2530	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of ovine COX2	B	5.62	pIC50	2400	nM	IC50	Eur J Med Chem (2009) 44: 1278-1287 [PMID:18835505]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX-2 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Eur J Med Chem (2016) 118: 250-258 [PMID:27131067]
ChEMBL	In vitro inhibition of ovine prostaglandin G/H synthase 2	B	5.62	pIC50	2400	nM	IC50	J Med Chem (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL	Inhibition of Ovine COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2893-2899 [PMID:27158139]
ChEMBL	In vitro inhibitory concentration against COX-2 enzyme	B	5.62	pIC50	2400	nM	IC50	J Med Chem (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL	Inhibitory activity against ovine COX2	B	5.62	pIC50	2400	nM	IC50	J Med Chem (2006) 49: 1668-1683 [PMID:16509583]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917]
Gamma-glutamyltranspeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5696] [UniProtKB: P19440]
ChEMBL	Inhibition of gamma-glutamyltranspeptidase by colorimetric assay	B	4.44	pIC50	36000	nM	IC50	Eur J Med Chem (2009) 44: 197-202 [PMID:18400337]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514]
ChEMBL	Inhibition of collagen-induced platelet aggregation	F	4	pIC50	>100000	nM	IC50	J Med Chem (1995) 38: 34-41 [PMID:7837237]
ChEMBL	Inhibition of arachidonic acid-induced platelet aggregation	F	5.3	pIC50	5000	nM	IC50	J Med Chem (1995) 38: 34-41 [PMID:7837237]
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6]
ChEMBL	Inhibition of NAPRT (unknown origin)	B	9.3	pKi	0.5	nM	Ki	WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (2017)
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb	-	-	4	pIC50	92000	nM	IC50	J Neurosci (2001) 21: 8026-33 [PMID:11588175]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]