nogapendekin alfa

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Ligands
nogapendekin alfa

GtoPdb Ligand ID: 11594

Synonyms: IL15 D72

Compound class: Peptide or derivative

Comment: Inogapendekin alfa is recombinant human IL-15 with an amino acid substitution (Asn72Asp/N72D) that enhances its agonist activity at the IL-15Rβγc complex. IL-15^N72D increases biological activity by 4-5-fold compared to the wild type cytokine. Inogapendekin alfa is synthesised in tandem with inbakicept to generate the clinical stage IL-15 superagonist complex ALT-803.

Summary
Biological activity
References
Structure
Similar ligands

References
1. Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA et al.. (2011) IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization. Cytokine, 56 (3): 804-10. [PMID:22019703]

References

1. Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA et al.. (2011)
IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization.
Cytokine, 56 (3): 804-10. [PMID:22019703]