nogapendekin alfa

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Ligands
nogapendekin alfa

GtoPdb Ligand ID: 11594

Synonyms: IL15 D72

Compound class: Peptide or derivative

Comment: Inogapendekin alfa is recombinant human IL-15 with an amino acid substitution (Asn72Asp/N72D) that enhances its agonist activity at the IL-15Rβγc complex. IL-15^N72D increases biological activity by 4-5-fold compared to the wild type cytokine. Inogapendekin alfa is synthesised in tandem with inbakicept to generate the clinical stage IL-15 superagonist complex ALT-803.

Summary
Biological activity
References
Structure
Similar ligands

Bioactivity Comments
Biological activity of IL-15^N72D compared to wild type IL-15 was determined by its effect on increasing spleen weight and white blood cell levels [1].

Bioactivity Comments

Biological activity of IL-15^N72D compared to wild type IL-15 was determined by its effect on increasing spleen weight and white blood cell levels [1].