GNF2133   Click here for help

GtoPdb Ligand ID: 10687

Synonyms: compound 13g [PMID: 32077280] | GNF-2133
PDB Ligand
Compound class: Synthetic organic
Comment: GNF2133 is a potent, selective and orally bioavailable inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) [3]. It was designed and reported by the Genomics Institute of the Novartis Research Foundation (GNF). Inhibition of DYRK1A is being examined as a mechanism to promote β-cell proliferation as a novel therapy for type I diabetes. GNF2133 is active in relevant in vivo models. Significantly, GNF2133 is devoid of glycogen synthase kinase-3β (GSK3β) inhibitory activity, which is considered to be a potential long-term treatment liability of pre-exisitng dual DYRK1A/GSK3β inhibitors [1].
See also compound 2-2c [PMID: 32003560], which is a selective DYRK1A inhibitor with a different chemical scaffold [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 75.52
Molecular weight 434.24
XLogP 2.02
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCN1CCN(CC1)C(=O)Nc1nccc(c1)c1cn(c2c1ccnc2)C1CCOCC1
Isomeric SMILES CCN1CCN(CC1)C(=O)Nc1nccc(c1)c1cn(c2c1ccnc2)C1CCOCC1
InChI InChI=1S/C24H30N6O2/c1-2-28-9-11-29(12-10-28)24(31)27-23-15-18(3-8-26-23)21-17-30(19-5-13-32-14-6-19)22-16-25-7-4-20(21)22/h3-4,7-8,15-17,19H,2,5-6,9-14H2,1H3,(H,26,27,31)
InChI Key SAZIAQSVBIWIDU-UHFFFAOYSA-N
References
1. Cohen P, Goedert M. (2004)
GSK3 inhibitors: development and therapeutic potential.
Nat Rev Drug Discov, 3 (6): 479-87. [PMID:15173837]
2. Kumar K, Wang P, Wilson J, Zlatanic V, Berrouet C, Khamrui S, Secor C, Swartz EA, Lazarus M, Sanchez R et al.. (2020)
Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.
J Med Chem, 63 (6): 2986-3003. [PMID:32003560]
3. Liu YA, Jin Q, Zou Y, Ding Q, Yan S, Wang Z, Hao X, Nguyen B, Zhang X, Pan J et al.. (2020)
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J Med Chem, 63 (6): 2958-2973. [PMID:32077280]