gemtuzumab ozogamicin   Click here for help

GtoPdb Ligand ID: 6775

Synonyms: CDP 771 | CMA 676 | hP67.6-calicheamicin | Mylotarg® | WAY-CMA 676
Approved drug Immunopharmacology Ligand
gemtuzumab ozogamicin is an approved drug (FDA (2000), EMA (2018))
Compound class: Antibody
Comment: This drug is an antibody-drug conjugate (ADC) that targets delivery of the highly cytotoxic ozogamicin (a derivative of calicheamicin γ1) to CD33 +ve myeloid cells [1].
Immunopharmacology Comments
Gemtuzumab ozogamicin is an immune checkpoint modulator that delivers a toxic payload to target cancer cells.
Immunopharmacology Disease
Disease X-Refs Comment References
Acute myeloid leukemia Disease Ontology: DOID:9119
OMIM: 601626
Orphanet: ORPHA519
Approved in particular for CD33-positive AML. However, note that use in this indication has been withdrawn in some jurisdictions due to safety concerns and lack of significant efficacy.