gemtuzumab ozogamicin   Click here for help

GtoPdb Ligand ID: 6775

Synonyms: CDP 771 | CMA 676 | hP67.6-calicheamicin | Mylotarg® | WAY-CMA 676
Approved drug Immunopharmacology Ligand
gemtuzumab ozogamicin is an approved drug (FDA (2000), EMA (2018))
Compound class: Antibody
Comment: This drug is an antibody-drug conjugate (ADC) that targets delivery of the highly cytotoxic ozogamicin (a derivative of calicheamicin γ1) to CD33 +ve myeloid cells [1].
Bioactivity Comments
We have been unable to find publicly available affinity data for the interaction between gemtuzumab and CD33 to substantiate its primary molecular target.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD33 Primary target of this compound Hs Antibody Binding - - - 1