IL-21   Click here for help

GtoPdb Ligand ID: 4987

Synonyms: interleukin-21 | ZA11
Immunopharmacology Ligand
Comment: IL-21 acts via the IL-21 receptor expressed on the surface of T, B and NK cells.
Species: Human
Immunopharmacology Comments
IL-21 is expressed by activated human CD4+ T cells, is upregulated in Th2 [5] and Th17 T helper cells [4] and T follicular cells. IL-21 regulates NK T cells in an autocrine manner.
Immunopharmacology Disease
Disease X-Refs Comment References
Lymphoma, non-hodgkin, familial Disease Ontology: DOID:0060060
OMIM: 605027
HL cancer cells produce IL-21 which could explain the clustering of other immune cells around HL cells observed in vitro. 3