Bioactivity Comments

IL-21 has been shown to eliminate glioblastoma multiforme cells via activation of the cytolytic reactivity of Vγ9Vδ2 T cells in vitro and in an in vivo model [2]. These findings suggest that IL-21-sensitized allogeneic human Vγ9Vδ2 T cells might offer a novel immunotherapeutic approach for the treatment of glioblastoma multiforme.

Natural/Endogenous Targets
Target Interleukin-21 receptor

Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference Interleukin-21 receptor Hs Agonist Agonist - - - ⤷

Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference avizakimab Hs Antibody Binding 10.0 – 12.0 pKd - 1 ⤷ pKd 10.0 – 12.0 (Kd 1x10-10 – 1x10-12 M) [1] Description: Estimated binding affinitiy, based on patent claims