alemtuzumab   Click here for help

GtoPdb Ligand ID: 6770

Synonyms: campath 1H | Campath® | campath-1H | Lemtrada®
Approved drug Immunopharmacology Ligand
alemtuzumab is an approved drug (FDA (2001), EMA (2013))
Compound class: Antibody
Comment: CAMPATH-1 (CD52) antigen inhibitor. Functionally, alemtuzumab causes depletion and then recovery of the immune system.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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No information available.
Summary of Clinical Use Click here for help
Alemtuzumab is primarily used for the treament of relapsing-remitting multiple sclerosis (RRMS). Based on results from clinical trials, the UK National Institute for Health and Care Excellence (NICE) approved use of this drug for RRMS in May 2014. In November 2014, the US FDA approved alemtuzumab for RRMS. A list of clinical trials for this drug in MS patients is available using this link to

Alemtuzumab can also be used in B-cell chronic lymphocytic leukemia (CLL) therapy and in transplant indications, but access for these indications is controlled through a patient access programme (in the UK). In other jurisdictions use for this indication has been discontinued.

Results from Phase 3 trial NCT00548405, suggest that treating RRMS patients with alemtuzumab earlier can actually improve preexisiting disability, rather than just slowing disease progression (with caveats around risk-benefit, and the serious side-effects of alemtuzumab therapy; side-effects such as infusion associated reactions, infections, and development of other autoimmune diseases) [3].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Hypothesised to act via the activation of antibody-dependent cell-mediated cytotoxicity.
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