Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	61	1p36.11	CD52	CD52 molecule
Mouse	-	74	4 66.5 cM	Cd52	CD52 antigen
Rat	-	96	5q36	Cd52	CD52 molecule

Previous and Unofficial Names

CAMPATH-1 antigen | myeloid cell surface antigen CD33

Database Links
Alphafold	P31358 (Hs), Q64389 (Mm), Q63064 (Rn)
ChEMBL Target	CHEMBL1912 (Hs)
DrugBank Target	P31358 (Hs)
Ensembl Gene	ENSG00000169442 (Hs), ENSMUSG00000000682 (Mm), ENSRNOG00000015403 (Rn)
Entrez Gene	1043 (Hs), 23833 (Mm), 117054 (Rn)
Human Protein Atlas	ENSG00000169442 (Hs)
KEGG Gene	hsa:1043 (Hs), mmu:23833 (Mm), rno:117054 (Rn)
OMIM	114280 (Hs)
Pharos	P31358 (Hs)
RefSeq Nucleotide	NM_001803 (Hs), NM_013706 (Mm), NM_053983 (Rn)
RefSeq Protein	NP_001794 (Hs), NP_038734 (Mm), NP_446435 (Rn)
UniProtKB	P31358 (Hs), Q64389 (Mm), Q63064 (Rn)
Wikipedia	CD52 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference alemtuzumab Hs Binding - - 1-2 ⤷ [1-2]
Antibody Comments
The anti-CD52 antibody GZ-402668 (GLD52; gatralimab) was developed by Sanofi for the treament of progressive multiple sclerosis. Having completed Phase 1 evaluation, Sanofi halted further development of this agent in early 2018.

Immunopharmacology Comments

CD52 (CAMPATH-1) is a short, glycosylphosphatidylinositol (GPI) anchored peptide expressed on lymphocytes and by cells of the male genital tract. CD52 is required for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. The approved monoclonal antibody, alemtuzumab targets this function of CD52. By attaching to sperm it may be associated with oocyte penetration and fertilisation.

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235) monocyte (CL:0000576)

Immuno Cell Type:  Natural killer cells

Immuno Cell Type:  B cells

Immuno Cell Type:  T cells