AL-78898A

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Ligands
AL-78898A

GtoPdb Ligand ID: 9219

Synonyms: 4(1MeW) [2] | POT-4

Compound class: Peptide or derivative

Comment: AL-78898A is an investigational analogue of compstatin [2], which acts as an irreversible inhibitor of complement component 3 (C3). C3 inhibitors are being actively investigated for clinical potential in inflammatory and degenerative diseases [1].

Summary
Biological activity
Clinical data
References
Structure
Immunopharmacology

Bioactivity Comments
Binds C3b with an equilibrium dissociation constant (K_D) of 10.3nM and inhibits complement (in a complement inhibition ELISA) with an IC₅₀ of 132nM [2].

Bioactivity Comments

Binds C3b with an equilibrium dissociation constant (K_D) of 10.3nM and inhibits complement (in a complement inhibition ELISA) with an IC₅₀ of 132nM [2].