AL-78898A   Click here for help

GtoPdb Ligand ID: 9219

Synonyms: 4(1MeW) [2] | POT-4
Immunopharmacology Ligand
Comment: AL-78898A is an investigational analogue of compstatin [2], which acts as an irreversible inhibitor of complement component 3 (C3). C3 inhibitors are being actively investigated for clinical potential in inflammatory and degenerative diseases [1].
No information available.
Summary of Clinical Use Click here for help
AL-78898A (POT4) has been investigated i Phase 2 clinical trial for neovascular age-related macular degeneration (AMD). Click here to link to's list of AL-78898A/POT-4 trials. See F1000Prime Rep. 2014; 6: 29 (Advances in the management of macular degeneration) for a review of recent research and development in this field.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Prevents activation of C3, the central component mediating activation of the classical, alternative, and lectin pathways of complement activation.