AL-78898A   Click here for help

GtoPdb Ligand ID: 9219

Synonyms: 4(1MeW) [2] | POT-4
Immunopharmacology Ligand
Comment: AL-78898A is an investigational analogue of compstatin [2], which acts as an irreversible inhibitor of complement component 3 (C3). C3 inhibitors are being actively investigated for clinical potential in inflammatory and degenerative diseases [1].
1. Morgan BP, Harris CL. (2015)
Complement, a target for therapy in inflammatory and degenerative diseases.
Nat Rev Drug Discov, 14 (12): 857-77. [PMID:26493766]
2. Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, DeAngelis RA, Resuello RR, Lupu F et al.. (2013)
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.
Immunobiology, 218 (4): 496-505. [PMID:22795972]