AL-78898A

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Ligands
AL-78898A

GtoPdb Ligand ID: 9219

Synonyms: 4(1MeW) [2] | POT-4

Comment: AL-78898A is an investigational analogue of compstatin [2], which acts as an irreversible inhibitor of complement component 3 (C3). C3 inhibitors are being actively investigated for clinical potential in inflammatory and degenerative diseases [1].

Summary
Biological activity
Clinical data
References
Structure
Immunopharmacology

References
1. Morgan BP, Harris CL. (2015) Complement, a target for therapy in inflammatory and degenerative diseases. Nat Rev Drug Discov, 14 (12): 857-77. [PMID:26493766]
2. Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, DeAngelis RA, Resuello RR, Lupu F et al.. (2013) New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology, 218 (4): 496-505. [PMID:22795972]

References

1. Morgan BP, Harris CL. (2015)
Complement, a target for therapy in inflammatory and degenerative diseases.
Nat Rev Drug Discov, 14 (12): 857-77. [PMID:26493766]

2. Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, DeAngelis RA, Resuello RR, Lupu F et al.. (2013)
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.
Immunobiology, 218 (4): 496-505. [PMID:22795972]