nemolizumab   Click here for help

GtoPdb Ligand ID: 8720

Synonyms: CD14152 | CIM 331 | CIM331
Immunopharmacology Ligand
Compound class: Antibody
Comment: Nemolizumab is an investigational monoclonal targeting the α subunit of the IL-31 receptor. Nemolizumab has been designed for treating or preventing inflammatory diseases [3].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide analysis of patented peptide sequences reveals that the heavy and light variable domains of nemolizumab are identical to SEQ ID NO: 210 and SEQ ID NO: 220 respectively, in patent US8575317 B2 [4]. This combination of peptides corresponds to one of the preferred antibodies, designated as H44L17 therein.
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-31 receptor, α subunit Primary target of this compound Hs Antibody Binding 8.7 pKd - 4
pKd 8.7 (Kd 2x10-9 M) [4]