nemolizumab   Click here for help

GtoPdb Ligand ID: 8720

Synonyms: CD14152 | CIM 331 | CIM331
Immunopharmacology Ligand
Compound class: Antibody
Comment: Nemolizumab is an investigational monoclonal targeting the α subunit of the IL-31 receptor. Nemolizumab has been designed for treating or preventing inflammatory diseases [3].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide analysis of patented peptide sequences reveals that the heavy and light variable domains of nemolizumab are identical to SEQ ID NO: 210 and SEQ ID NO: 220 respectively, in patent US8575317 B2 [4]. This combination of peptides corresponds to one of the preferred antibodies, designated as H44L17 therein.
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Immunopharmacology Comments
Nemolizumab is a first-in-class investigational monoclonal antibody that targets the α subunit of the IL-31 receptor [3]. IL-31 is a cytokine with a key role in driving the pathogenesis of moderate-to-severe atopic dermatitis. Nemolizumab blocks the IL-31 signalling pathway.