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Interleukin-31 receptor, α subunit

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1710

Nomenclature: Interleukin-31 receptor, α subunit

Family: IL-6 receptor family

Quaternary Structure: Complexes
Interleukin-31 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 732 5q11.2 IL31RA interleukin 31 receptor A
Mouse 1 716 13 D2.2 Il31ra interleukin 31 receptor A
Rat - 718 2q14 Il31ra interleukin 31 receptor A
Previous and Unofficial Names Click here for help
CRL | CRL3 | interleukin-31 receptor subunit alpha | GPL | Glmr | NR10 [1]
Database Links Click here for help
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
nemolizumab Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding 8.7 pKd 1
pKd 8.7 (Kd 2x10-9 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0043031 negative regulation of macrophage activation NAS
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GO:0002438 acute inflammatory response to antigenic stimulus IEA
GO:0035745 T-helper 2 cell cytokine production IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0043031 negative regulation of macrophage activation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0030224 monocyte differentiation IEP
GO:0030225 macrophage differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway TAS
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GO:0035745 T-helper 2 cell cytokine production IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043031 negative regulation of macrophage activation NAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0035745 T-helper 2 cell cytokine production IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0035745 T-helper 2 cell cytokine production IEA
General Comments
The IL-31 receptor subunit α functions a monomer and as part of a receptor complex with the oncostatin M receptor (OSMR). It is a type I cytokine receptor that is involved in IL-31 signalling which is mediated via activation of STAT3 and STAT5.

References

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1. Kuramochi T, Kasutani K, Ohyama S, Tsunoda H, Igawa T, Tachibana T, Shiraiwa H, Esaki K. (2013) Anti-NR10 antibody and use thereof. Patent number: US8575317 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 05/12/2007. Publication date: 05/11/2013.

How to cite this page

IL-6 receptor family: Interleukin-31 receptor, α subunit. Last modified on 17/10/2018. Accessed on 03/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1710.