Synonyms: compound 99 [PMID 25380412]
Compound class:
Synthetic organic
Comment: GLPG0974 is a lead clinical development candidate compound which acts as an antagonist of the free fatty acid receptor 2 (FFA2) [3]. FFA2 is a GPCR involved in the mediation of inflammatory responses.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
GLPG0974 is reported to be selective for FFA2 [3] in a panel of 55 receptors, ion channels, and transporters tested in the Cerep ExpresSProfile selectivity set [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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