CXCL10   Click here for help

GtoPdb Ligand ID: 835

Immunopharmacology Ligand
Comment: CXCL10 is a C-X-C motif chemokine preferentially expressed by Th1 lymphocytes. It exerts its biological effects via interaction with the CXCR3 GPCR.
Species: Human
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Natural/Endogenous Targets
Target
CCR3
CXCR3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 7.8 – 9.8 pKi - 2,4
pKi 7.8 – 9.8 [2,4]
CCR3 Ligand is endogenous in the given species Hs Antagonist Antagonist - - -
Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
eldelumab Peptide Primary target of this compound Hs Antibody Binding 9.1 pKd - 1
pKd 9.1 (Kd 7.2x10-10 M) [1]