CXCL10   Click here for help

GtoPdb Ligand ID: 835

Immunopharmacology Ligand
Comment: CXCL10 is a C-X-C motif chemokine preferentially expressed by Th1 lymphocytes. It exerts its biological effects via interaction with the CXCR3 GPCR.
Species: Human
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Immunopharmacology Comments
CXCL10 expression is induced by IFN-γ, and is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes under the proinflammatory effect of IFN-γ. CXCL10 expression is associated with the Th1 immune response and leukocyte homing to inflamed tissues, and this results in exacerbated inflammation and tissue damage [3]. It is also a chemoattractant for monocytes and NK cells. In humans, CXCL10 has been shown to be involved in the pathological processes underlying infectious diseases, inflammatory and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome and systemic sclerosis) [3], and cancer. CXCL10 also has anti-angiogenesic activity which confers anti-tumor effects.