ZM-306416   Click here for help

GtoPdb Ligand ID: 8245

Synonyms: CB-676475 | ZM 306416 | ZM306416
Compound class: Synthetic organic
Comment: ZM-306416 is reported as an inhibitor of VEGFR and EGFR [1]. Hennequin et al (1999) report selectivity for VEGFR2 (KDR) over VEGFR1 (Flt-1) [2] (ZM-306416 is compound 4 in [2]).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 56.27
Molecular weight 333.07
XLogP 3.37
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc2c(ncnc2cc1OC)Nc1ccc(cc1F)Cl
Isomeric SMILES COc1cc2c(ncnc2cc1OC)Nc1ccc(cc1F)Cl
InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
epidermal growth factor receptor Hs Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
kinase insert domain receptor Hs Inhibitor Inhibition 7.0 pIC50 - 2
pIC50 7.0 (IC50 1x10-7 M) [2]
fms related receptor tyrosine kinase 1 Hs Inhibitor Inhibition 5.7 – 6.5 pIC50 - 1-2
pIC50 5.7 – 6.5 (IC50 2x10-6 – 3.3x10-7 M) [1-2]