ChEMBL ligand: CHEMBL150315 (CB-676475)
EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL	Equilibrium binding constant for EPH receptor B2	B	5.21	pKd	6200	nM	Kd	J Med Chem (2005) 48: 3221-3230 [PMID:15857128]
ChEMBL	Inhibition of EPH receptor B2 using ELISA	B	5.07	pIC50	8500	nM	IC50	J Med Chem (2005) 48: 3221-3230 [PMID:15857128]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	FGFR-1 (FTK) inhibitory activity at 2 uM of ATP in vitro.	B	5.15	pIC50	7000	nM	IC50	J Med Chem (1999) 42: 5369-5389 [PMID:10639280]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL	Inhibition of VEGFR1	B	4.75	pIC50	17700	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3177-3181 [PMID:20403693]
ChEMBL	Inhibition of VEGFR1 expressed in human tumor cells	B	4.75	pIC50	17700	nM	IC50	Bioorg Med Chem (2008) 16: 5514-5528 [PMID:18467105]
ChEMBL	Inhibition of VEGF-induced VEGFR1 autophosphorylation in human A498 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by phosphotyrosine ELISA	B	4.75	pIC50	17700	nM	IC50	Bioorg Med Chem (2012) 20: 2444-2454 [PMID:22370340]
ChEMBL	Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISA	B	4.85	pIC50	14100	nM	IC50	Bioorg Med Chem (2012) 20: 910-914 [PMID:22204741]
ChEMBL	Inhibition of VEGF-induced VEGFR1 phosphorylation in human A498 cells overexpressing Flt-1 pretreated for 60 mins prior to VEGF addition measured after 10 mins by phosphotyrosine ELISA cytoblot analysis	B	4.85	pIC50	14100	nM	IC50	Bioorg Med Chem (2013) 21: 1312-1323 [PMID:23375090]
ChEMBL	Inhibition of VEGFR1 in human A498 cells by phosphotyrosine cell-based ELISA	B	4.85	pIC50	14100	nM	IC50	J Med Chem (2010) 53: 1563-1578 [PMID:20092323]
ChEMBL	Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISA	B	4.85	pIC50	14100	nM	IC50	Bioorg Med Chem (2010) 18: 3575-3587 [PMID:20403700]
ChEMBL	Inhibitory activity against flt kinase	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 129-133 [PMID:16216503]
ChEMBL	In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 uM of ATP.	B	5.7	pIC50	2000	nM	IC50	J Med Chem (1999) 42: 5369-5389 [PMID:10639280]
GtoPdb	-	-	6.48	pIC50	330	nM	IC50	J Biomol Screen (2012) 17: 885-99 [PMID:22573732]; J Med Chem (1999) 42: 5369-89 [PMID:10639280]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibitory activity against VEGFR2 kinase	B	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem Lett (2006) 16: 129-133 [PMID:16216503]
GtoPdb	-	-	7	pIC50	100	nM	IC50	J Med Chem (1999) 42: 5369-89 [PMID:10639280]
ChEMBL	Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP in vitro.	B	7	pIC50	100	nM	IC50	J Med Chem (1999) 42: 5369-5389 [PMID:10639280]
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb	-	-	8	pIC50	10	nM	IC50	J Biomol Screen (2012) 17: 885-99 [PMID:22573732]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]