eculizumab

Ligand id: 6884

Name: eculizumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Eculizumab binds to and blocks the cleavage of the complement protein C5, thereby preventing the formation of C5a. The terminal half-life of eculizumab is 11.3 ± 3.4 days [3].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C5 Hs Antibody Binding 9.2 – 10.5 pKd - 1,4
pKd 10.5 (Kd 3x10-11 M) [4]
Description: At pH7.4 in a SPR assay.
pKd 10.5 (Kd 3x10-11 M) [1]
pKd 9.2 (Kd 6x10-10 M) [4]
Description: At pH6.0 in a SPR assay.