eculizumab

Ligand id: 6884

Name: eculizumab

References
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Methods and compositions for the treatment of glomerulonephritis and other inflammatory diseases.
Patent number: WO1995029697A1. Assignee: Alexion Pharma Inc.. Priority date: 02/05/1994. Publication date: 09/11/1995.
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Complement-targeted therapy: development of C5- and C5a-targeted inhibition.
Inflamm Regen, 36: 11. [PMID:29259684]
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Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria.
Nat. Biotechnol., 25 (11): 1256-64. [PMID:17989688]
4. Sheridan D, Yu ZX, Zhang Y, Patel R, Sun F, Lasaro MA, Bouchard K, Andrien B, Marozsan A, Wang Y et al.. (2018)
Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action.
PLoS ONE, 13 (4): e0195909. [PMID:29649283]