ICAM-1   Click here for help

GtoPdb Ligand ID: 6757

Comment: ICAM-1 is a cell-adhesion molecule that is overexpressed on the surface of a number of cancer cells types [1,5], and this may be correlated with metastasis and poor prognosis [3]. These findings suggest ICAM-1 as an ideal target for oncology therapeutic development [2]. Monoclonal antibodies (and antibody-drug conjugates) that target ICAM-1 are being explored for anti-tumour potential [4,6-7], and there is a report of the experimental effect of ICAM-1 targeting CAR-T cells in triple-negative breast cancer [8].
Species: Human
Additional information and targets (data relate to human unless otherwise stated)
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