ICAM-1   Click here for help

GtoPdb Ligand ID: 6757

Compound class: Endogenous peptide in human, mouse or rat
Comment: ICAM-1 is a cell-adhesion molecule that is overexpressed on the surface of a number of cancer cells types [1,5], and this may be correlated with metastasis and poor prognosis [3]. These findings suggest ICAM-1 as an ideal target for oncology therapeutic development [2]. Monoclonal antibodies (and antibody-drug conjugates) that target ICAM-1 are being explored for anti-tumour potential [4,6-7], and there is a report of the experimental effect of ICAM-1 targeting CAR-T cells in triple-negative breast cancer [8].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ICAM1 intercellular adhesion molecule 1 Human prepro-intercellular adhesion molecule 1 BB2, CD54, human rhinovirus receptor
Database Links Click here for help
CATH/Gene3D 2.60.40.10
DrugBank Target P05362 (Hs)
Ensembl Gene ENSG00000090339 (Hs)
Entrez Gene 3383 (Hs)
GtoPdb PubChem SID 178103368
Human Protein Atlas ENSG00000090339 (Hs)
Immunopaedia Search ICAM-1
UniProtKB P05362 (Hs)
Wikipedia ICAM1